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Quantum White Paper


The Scientific Rationale Behind Combining Caffeine + Macronutrients for Sustained Energy Delivery Required in Endurance Sports

About the author: Bob Murray, PhD, FACSM, is founder and principal of Sports Science Insights, LLC. Bob previously served as director of the Gatorade Sports Science Institute (GSSI) from 1985 to 2008. Dr. Murray oversaw a broad program of GSSI and university- based research in exercise science and sports nutrition designed to set industry standards and consumer expectations for science-based product efficacy. Bob has been an invited speaker at sports science and nutrition conferences around the world. An author of numerous publications in scientific texts and journals, Dr. Murray is a Fellow of the American College of Sports Medicine and served on the ACSM Board of Trustees.

Product Description
Quantum Energy Squares are coffee-infused energy bars available in four flavors: Dark Chocolate Almond, Crunchy Peanut Butter, Caffe Mocha Macchiato, and Coconut. Each 1.69-oz (48-g) bar contains 200-220 kcal, 19-21 grams carbohydrate (including 11 grams sugar), 10 grams protein, 10-12 grams fat, 26-47 milligrams calcium, 1-3 mg iron, 205-239 milligrams potassium, and 100 milligrams of caffeine from organic green coffee beans (similar to the caffeine content of one cup of coffee). In addition, the products are certified vegan, non-GMO, gluten- free, and soy-free.

Quantum Energy Squares are formulated by combining organic green coffee beans with macronutrients from fruits, nuts, grains, and seeds to provide a slow, long-lasting energy boost and appetite suppression, along with natural antioxidants, vitamins, and minerals from real food ingredients such as almonds, pea protein, pumpkin seeds, quinoa, chia seeds, cherries, dates, dark chocolate, and monk fruit. Each Quantum Energy Squares bar is comprised of approximately 35-42% energy (kcal) from carbohydrate, 18-20% energy from protein, 40-50% energy from fat, and 4 grams of dietary fiber. (Values vary depending on product flavor.)

Product Attributes
Natural energy from organic green coffee. Caffeine and its metabolites (theobromine, theophylline, paraxanthine) stimulate neurotransmitter release from nerve cells throughout the body, especially in the brain, contributing to an increased sense of energy, focus, and alertness. Caffeine also increases the contractile capacity of skeletal muscles and reduces the perception of pain, discomfort, and perceived exertion. Urine production is also increased by caffeine, but that is a modest effect, particularly in regular caffeine users and has no impact on daily hydration status or exercise performance. Green coffee beans contain a variety of natural compounds that include polyphenols such as chlorogenic acid (CGA). Some studies of daily CGA consumption in humans have reported benefits to weight loss, blood sugar control, inflammation, and blood pressure. Within 15 minutes after ingestion, caffeine appears in the bloodstream and its concentration usually peaks after 45 to 60 minutes,1 depending upon the amount and form of caffeine intake. The half-life of caffeine—the time it takes for half of the ingested dose to be removed from the bloodstream—can be 3 to 10 hours, depending on the individual. Caffeine is removed from the blood by the liver, relying on cytochrome P450 1A2, the liver enzyme responsible for over 90% of caffeine metabolism. P450 metabolizes caffeine into paraxanthine, theophylline, and theobromine, all of which also have stimulatory effects. Some people have the fast genetic variant of this enzyme, while others have the slower version. Those with the fast variant seem to have a greater sensitivity to the performance-enhancing (ergogenic) benefits of caffeine, suggesting that caffeine metabolites play an important role in improved performance. There may also be genetic variations in adenosine receptors that contribute to the ergogenicity of caffeine. The same may be true for caffeine’s other mechanisms of action (e.g., adrenalin
release, neural firing rates, muscle contraction, etc.)

Caffeine temporarily relieves drowsiness by competing with adenosine molecules on various adenosine receptors (A1, A2a, A2b, A3) on nerves in the brain (and in other tissues such as skeletal muscle).1,8-10 Adenosine is a naturally produced molecule that accumulates throughout the day; too much adenosine activates adenosine receptors, producing drowsiness. Caffeine has a molecular structure similar to adenosine and reduces the effects of adenosine by temporarily binding to the same receptors without activating them.1,8,9,11 Interestingly, the caffeine content one cup of coffee or one Quantum Energy Squares bar (100 mg) affects less than 20% of the total adenosine receptors. Research has shown that low doses of caffeine (e.g., 40-60 mg; the amount found in many caffeinated soft drinks) increase feelings of energy, alertness, and mental focus and there is evidence that physical performance can be improved with caffeine doses as low as 100 mg (e.g., 0.7 mg caffeine/lb body weight).

There is a large variability among people in their responses to caffeine ingestion; however, it is abundantly clear that caffeine ingestion is associated with ergogenic benefits in most people. Caffeine is associated with improved physical and mental performance responses when consumed before exercise as well as during exercise.Research suggests that for a performance benefit to occur, higher blood caffeine levels are required to be achieved before exercise compared to during exercise when lower blood caffeine levels appear to effectively enhance performance, possibly because exercise increases the sensitivity of adenosine receptors to caffeine.

In summary, the scientific literature confirms that consuming caffeine in amounts similar to that found in Quantum Energy Squares (100 mg) is associated with improved mental and physical function when ingested before and/or during demanding exercise. A unique attribute of Quantum Energy Squares is the intent that caffeine delivery into the bloodstream be prolonged as a result of the macronutrient content of the bars (complex carbohydrates and plant proteins), ensuring that plasma caffeine concentrations are maintained for a longer time, a benefit that could be described as “sustained energy by design.” When caffeine is consumed in a liquid, or in a capsule, or in chewing gum, there is a rapid rise in blood caffeine levels, followed by gradual clearance from the blood.1,15 The intent of Quantum Energy Squares is to prolong the positive effects of caffeine on focus, alertness, and performance by slowing its entry into the blood. A long-lasting boost with healthy fats from nuts, grains, and seeds.

Quantum Energy Squares contain almonds, peanuts, organic quinoa, chia seeds, pumpkin seeds, and coconut, all of which contribute healthy fats to the product. Fats in the diet are classified by their molecular structure, specifically by the number and position of unsaturated bonds between carbon molecules. Fats—more accurately the fatty acids that comprise fats—are long chains of carbon molecules, varying in length from 12 to 22 carbons for the most common fatty acids found in the diet. Saturated fatty acids contain no double bonds between any of the carbon molecules; in other words, their carbon chains are fully saturated. Monounsaturated fatty acids contain one double bond and polyunsaturated fatty acids contain more than one double bond. To optimize cardiovascular health and body weight, current recommendations from a variety of professional and governmental organizations such as the Academy of Nutrition and Dietetics, American Heart Association, and the U.S. Institute of Medicine are to minimize the consumption of saturated fats and increase the consumption of mono- and polyunsaturated fats (such as alpha-linoleic acid [ALA], linoleic acid [LA], eicosapentaenoic acid [EPA], docosapentaenoic acid [DPA], docosahexaenoic acid [DHA]) from fish, vegetables, grains, nuts, and seeds.16 The nuts, grains, and seeds in Quantum Energy Squares provide these healthy fatty acids. The fat we consume in our diets is an important energy source at rest and during exercise. Fatty acids from the foods we eat and from the fat we store is metabolized (oxidized) by active muscles to provide the fuel (ATP) required to sustain muscle contractions.17 Physically active people have increased energy (calorie) needs and fats in the diet contribute to meeting that need. The healthy-fat content of

Quantum Energy Squares helps active individuals meet their increased daily energy needs and likely helps slow the entry of caffeine into the bloodstream and extend the benefits of caffeine on mental and physical performance. Plant proteins for recovery and adaptation. Active bodies use the amino acids provided by dietary proteins to support the repair and remodeling of muscle tissue after hard workouts and competitions.19 Proteins in the diet are supplied by animal and plant sources such as beef, poultry, pork, fish, dairy, grains, beans, nuts, and seeds. Dietary proteins are digested into the individual amino acids that are used as the building blocks for the hundreds of thousands of different proteins in the body (e.g., structural proteins, enzymes, contractile proteins, regulatory proteins, etc.) There are only 20 amino acids and nine of those are referred to as essential amino acids that must be supplied by the diet; the other amino acids—the nonessential amino acids—can be produced in body cells. Under normal circumstances, our diets contain sufficient plant and animal proteins to meet our daily needs for the essential amino acids critical for muscle repair and remodeling. The 10 grams of plant protein in Quantum Energy Squares are from peas, pumpkin seeds, almonds, peanuts, chia seeds, and quinoa (plant-protein mix varies among flavors). Research suggests that combinations of various plant proteins can deliver an amino-acid profile that contains sufficient essential amino acids—leucine being of particular importance—to stimulate muscle protein synthesis. In this regard, consuming Quantum Energy Squares soon after exercise will provide proteins that will stimulate muscle protein synthesis, consistent with current dietary recommendations for active individuals. Wholesome carbohydrates to energize muscles. Active muscles rely on carbohydrate to produce the energy required to sustain muscle contraction; the greater the intensity of exercise, the more muscles depend on carbohydrate as fuel.

The carbohydrate content of Quantum Energy Squares (about 20 g/bar) is derived from organic quinoa, dates, chia seeds, monk fruit, agave syrup, tapioca syrup, tart cherries (one flavor), and dark chocolate chips, as well as carbohydrate provided by other nuts, grains, and seeds found in the products. The carbohydrate in Quantum Energy Squares is a combination of complex and simple carbohydrates found in most diets. Dietary carbohydrates include simple sugars (e.g., mono- and disaccharides such as glucose, sucrose, fructose), starches (e.g., amylose and amylopectin), and non-digestible fibers.25 All of the different types of carbohydrates found in the diet—with the exception of non-digestible fibers—are digested in the small intestine and absorbed into the
bloodstream as monosaccharides (e.g., glucose, fructose, galactose). Virtually all of the fructose and galactose molecules are converted by the liver into glucose molecules, the sugar used by cells throughout the body to produce the ATP energy required for cell function. Glucose is especially important for the function of the brain and is the preferred fuel for active muscles, either as glucose taken up from the bloodstream or as glucose molecules derived from muscle glycogen. The simple sugars in Quantum Energy Squares provide a source of rapidly absorbed carbohydrate to help maintain blood glucose concentration during intense and prolonged exercise, while the complex carbohydrates are digested and absorbed more slowly to provide a metered entry of glucose into the bloodstream. Such a combination of low-glycemic (complex carbohydrates) and high-glycemic (simple sugars) carbohydrates can deliver the glycemic, metabolic, and hormonal benefits associated with both rapid and prolonged carbohydrate absorption. Consuming carbohydrates before and during demanding exercise is associated with
improved mental and physical performance,23-25 a benefit that compliments the ergogenic effects of ingesting modest amounts of caffeine.32-35 Quantum Energy Squares bars take advantage of that well-established science to deliver palatable and effective nutritional support to individuals wanting to get the most from their bodies during training and competition.


References
1. McLellan TM, Caldwell JA, Lieberman HR. A review of caffeine's effects on cognitive, physical and occupational
performance. Neuroscience and Biobehavioral Reviews. 2016;71:294-312.
2. Wilhelmus MM, Hay JL, Zuiker RG, et al. Effects of a single, oral 60 mg caffeine dose on attention in healthy
adult subjects. Journal of Psychopharmacology. 2017;31(2):222-232.
3. Tallis J, Duncan MJ, James RS. What can isolated skeletal muscle experiments tell us about the effects of
caffeine on exercise performance? British Journal of Pharmacology. 2015;172(15):3703-3713.
4. Pethick J, Winter SL, Burnley M. Caffeine ingestion attenuates fatigue-induced loss of muscle torque
complexity. Medicine and Science in Sports and Exercise. 2017.
5. Southward K, Rutherfurd-Markwick KJ, Ali A. Correction to: The effect of acute caffeine ingestion on endurance
performance: a systematic review and meta-analysis. Sports Medicine. 2018;48(10):2425-2441.

5. Gonzalez-Alonso J, Heaps CL, Coyle EF. Rehydration after exercise with common beverages and water.
International Journal of Sports Medicine. 1992;13(5):399-406.
6. Armstrong LE, Casa DJ, Maresh CM, Ganio MS. Caffeine, fluid-electrolyte balance, temperature regulation, and
exercise-heat tolerance. Exercise and Sport Sciences Reviews. 2007;35(3):135-140.

7. Southward K, Rutherfurd-Markwick K, Badenhorst C, Ali A. The role of genetics in moderating the inter-
Individual differences in the ergogenicity of caffeine. Nutrients. 2018;10(10).

8. Guest N, Corey P, Vescovi J, El-Sohemy A. Caffeine, CYP1A2 genotype, and endurance performance in
athletes. Medicine and Science in Sports and Exercise. 2018;50(8):1570-1578.
9. Fredholm BB. Astra Award Lecture. Adenosine, adenosine receptors and the actions of caffeine. Pharmacol
Toxicol. 1995;76(2):93-101.
10. Meeusen R, Roelands B, Spriet LL. Caffeine, exercise and the brain. Nestle Nutrition Institute Workshop Series.
2013;76:1-12.
11. Pickering C, Kiely J. Are the current guidelines on caffeine use in sport optimal for everyone? Inter-individual
variation in caffeine ergogenicity, and a move towards personalised sports nutrition. Sports Medicine. 2017.
12. Spriet LL. Exercise and sport performance with low doses of caffeine. Sports Medicine. 2014;44 Suppl 2:S175-
184.
13. Hogervorst E, Bandelow S, Schmitt J, et al. Caffeine improves physical and cognitive performance during
exhaustive exercise. Medicine and Science in Sports and Exercise. 2008;40(10):1841-1851.
14. Wickham KA, Spriet LL. Administration of caffeine in alternate forms. Sports Medicine. 2018;48(Suppl 1):79-91.
16. Vannice G, Rasmussen H. Position of the Academy of Nutrition and Dietetics: dietary fatty acids for healthy
adults. J Acad Nutr Diet. 2014;114:136-153.
17. Thomas TD, Erdman KA, Burke LM. Nutrition and athletic performance. Medicine and Science in Sports and
Exercise. 2016;48(3):543-568.
18. Fleisher D, Li C, Zhou Y, Pao LH, Karim A. Drug, meal and formulation interactions influencing drug absorption
after oral administration. Clinical implications. Clinical Pharmacokinetics. 1999;36(3):233-254.
19. McGlory C, van Vliet S, Stokes T, Mittendorfer B, Phillips SM. The impact of exercise and nutrition in the
regulation of skeletal muscle mass. Journal of Physiology. 2018; pub before print.
20. Institute of Medicine. Proteins and amino acids. Dietary Reference Intakes for Energy, Carbohydrates, Fiber,
Fat, Fatty Avids, Cholesterol, Protein, and Amino Acids. Washington, DC: National Academy of Sciences;
2005:589-768.
21. van Vliet S, Burd NA, van Loon LJ. The skeletal muscle anabolic response to plant- versus animal-based protein
consumption. Journal of Nutrition. 2015;145(9):1981-1991.
22. Gorissen SHM, Crombag JJR, Senden JMG, et al. Protein content and amino acid composition of commercially
available plant-based protein isolates. Amino Acids. 2018;50(12):1685-1695.
23. Thomas TD, Erdman KA, Burke LM. Nutrition and athletic performance. Medicine and Science in Sports and
Exercise. 2016;48(3):543-568.
24. Hawley JA, Leckey JJ. Carbohydrate dependence during prolonged, intense endurance exercise. Sports
Medicine. 2015;45 Suppl 1:S5-12.
25. Helge JW. A high carbohydrate diet remains the evidence based choice for elite athletes to optimise
performance. Journal of Physiology. 2017;595(9):2775.

26. Institute of Medicine. Dietary carbohydrates, sugars and starches. Dietary Reference Intakes for Energy,
Carbohydrates, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: National
Academy of Sciences; 2005:265-338.
27. Murray B, Rosenbloom C. Fundamentals of glycogen metabolism for coaches and athletes. Nutrition Reviews.
2018;76(4):243-259.
28. Collier G, McLean A, O'Dea K. Effect of co-ingestion of fat on the metabolic responses to slowly and rapidly
absorbed carbohydrates. Diabetologia. 1984;26(1):50-54.
29. Painter JE, Prisecaru VI. The effects of various protein and carbohydrate ingredients in energy bars on blood
glucose levels in humans. Cereal Foods World. 2002;47(6):236-241.
30. Wu CL, Williams C. A low glycemic index meal before exercise improves endurance running capacity in men.
International Journal of Sport Nutrition and Exercise Metabolism. 2006;16(5):510-527.
31. Donaldson CM, Perry TL, Rose MC. Glycemic index and endurance performance. International Journal of Sport
Nutrition and Exercise Metabolism. 2010;20(2):154-165.
32. Black CD, Waddell DE, Gonglach AR. Caffeine's ergogenic effects on cycling: neuromuscular and perceptual
factors. Medicine and Science in Sports and Exercise. 2015;47(6):1145-1158.
33. Goldstein ER, Ziegenfuss T, Kalman D, et al. International society of sports nutrition position stand: caffeine and
performance. Journal of the International Society of Sports Nutrition. 2010;7(1):5.
34. Cole M, Hopker JG, Wiles JD, Coleman DA. The effects of acute carbohydrate and caffeine feeding strategies
on cycling efficiency. Journal of Sports Sciences. 2018;36(7):817-823.
35. Yeo SE, Jentjens RL, Wallis GA, Jeukendrup AE. Caffeine increases exogenous carbohydrate oxidation during
exercise. Journal of Applied Physiology. 2005;99(3):844-850.